To hear Oliver Smithies tell it, there was a direct line from one of his first lab projects to the experiments that won him a Nobel Prize. Smithies showed that it was possible to target genes for disruption in mice, a technique that has revolutionized genetics and provided information relevant to human health.Â
You wouldn't have guessed it based on the first slide of his talk at the Lindau Nobel Laureates meeting taking place this week in Germany. The slide showed an early page from Smithies' lab notebook of a failed attempt to isolate insulin, an experiment that he had dragged himself into the lab to perform on New Year's Day.Â
By showing page after page of his notebook to the audience, Smithies gradually told the tale of how failing to purify insulin eventually led him to a successful scientific career.
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